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Finally, we explored the therapeutic effect of FOXO4-DRI in naturally aged mice, and demonstrated that FOXO4-DRI alleviates age-related testosterone secretion insufficiency and improves the testicular microenvironment

116,117 Major changes in BBB structure and transport function have been observed during healthy ageing

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Additionally, studies show that iron chelators play a role in vasospasm-induced secondary ischemia, and their mechanism might involve inhibiting iron-induced ROS and lipid peroxidation, indicating that iron overload may influence the development of DBI

For the annulus fibrosus (the outer ring of the disc made primarily of collagen), this mechanism may support healing of small tears and prevent further deterioration